86 Incidence of Pulmonary Thromboembolism in Canadian Children: A 3-Year National Surveillance Study

Abstract Introduction/Background Pulmonary thromboembolism (PTE) is a rare but life-threatening event for which adequate epidemiological data in paediatrics are lacking. Best estimates regarding the epidemiology of PTE Canadian children were published over two decades ago, using information obtained from national registry paediatric thromboembolic disease only examined pulmonary embolism as related complication. It likely that true rates higher. Objectives To determine minimum incidence (neonate up to <18 years) by age, gender, and province / territory residence an existing surveillance system. Design/Methods Through Paediatric Surveillance program, 2,800 paediatricians subspecialists practicing Canada contacted monthly January 2020 December 2022. Using standardized definition pre-specified diagnostic criteria, clinicians requested report all new suspected or confirmed cases. Results During 3-year study period, 58 cases reported, documenting average annual 2.4 per million children. Females accounted 77.6% (n=45) Patients ranged age 2 months 17.9 years (median 15.8 years; interquartile rate 13.3 16.7 years). Incidence (reported children) varied age: 0-4 years, 0.7; 5-9 0.2; 10-14 2.0; 15-18 6.6; also province: Newfoundland, 21.3; Saskatchewan, 4.6; British Columbia, 4.5; New Brunswick, 4.4; Alberta, 3.5; Nova Scotia, 1.8; Ontario, 1.6; Manitoba, 1.0; Quebec, 0.9. Conclusion Although overall children, adolescents, particularly females, appear be at highest risk disease. not clear whether geographic distribution disproportionate provincial census may regional differences practices, population-related factors (e.g., obesity, genetic thrombophilias, OCP prescribing), reporting